List of vaccine-associated signals (15 items)
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Myocarditis (inflammation of heart muscle)
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What: Chest pain, shortness of breath, palpitations.
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Which vaccines: Mainly associated with mRNA vaccines (Pfizer-BioNTech, Moderna).
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How common: Highest risk in young males after the 2nd dose — studies reported tens of cases per million doses in adolescent/young adult males (e.g., ~50–105 per million in some age-sex groups). In general adult populations estimates are lower (single-digit to low-double-digit cases per million). JAMA Network+1
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Pericarditis (inflammation of the heart lining)
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What: Chest pain relieved by sitting up, pericardial rub; often occurs with/after myocarditis.
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Which vaccines: Also linked to mRNA vaccines.
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How common: Similar order of magnitude to myocarditis but variable by age/sex; often mild and self-limited. PubMed+1
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Guillain-Barré syndrome (GBS)
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What: Progressive muscle weakness and numbness; can be severe.
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Which vaccines: Signal stronger for adenoviral-vector vaccines (e.g., AstraZeneca / Vaxzevria, Johnson & Johnson) in several studies; less signal for mRNA vaccines.
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How common: Rare — observed increases in some datasets within ~6 weeks after vaccination; absolute numbers are small but statistically detectable in large cohorts. PMC+1
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